Oxidative Stress, Inflammation, and Vascular Aging in Hypertension
نویسندگان
چکیده
منابع مشابه
Oxidative Stress, Inflammation, and Vascular Aging in Hypertension.
Age-related decline in function is a physiological phenomenon occurring in all organ systems. However, acceleration and early occurrence of this process are observed in cardiovascular pathologies, including hypertension. In the vascular system, this is characterized by progressive pathological remodeling with stiffening, typically associated with extracellular matrix (ECM) alterations in collag...
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Hypertension is a major public health problem worldwide, affecting over 50 million individuals in the United States alone. The modern history of hypertension begins with the understanding of the cardiovascular system with the work of the physician William Harvey (1578–1657), who described the circulation of blood in his book De Motu Cordis. The English clergyman Stephen Hales made the first pub...
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Hypertension is a complex condition and is the most common cardiovascular risk factor, contributing to widespread morbidity and mortality. Approximately 90% of hypertension cases are classified as essential hypertension, where the precise cause is unknown. Hypertension is associated with inflammation; however, whether inflammation is a cause or effect of hypertension is not well understood. The...
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Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade infl...
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Background Inflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases. Methodology The influence of pathophysiolo...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2017
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.117.07802